Endocrine Abstracts

Introduction: The caloric expenditure and thermogenesis are very important aspects in the obesity problem, mostly underestimated. The ‘Protein Leverage Hypothesis’ (PLH) promotes the effect of satiety, delaying the hunger sensation; thus entails the regulation of caloric intake and body weight, as well as, the modification of thermogenic activity and energy expenditure. However, the effect of high protein diet over the physiological components of energy expenditure h...

Background: Optimal glucose management in older people is currently unclear. Recent guidelines recommend avoiding tight glycemic targets in elderly patients with comorbidities because intensive control is unlikely to achieve benefit and they are at higher risk of hypoglycaemia.Objective: To estimate the prevalence of potential overtreatment in older adults with diabetes mellitus and comorbidities.Design: Cross-sectional study.<...

Introduction: Testosterone treatment in female-to-male transsexuals has been associated with worsened cardiovascular risk factors, acne, male-pattern baldness and more rarely with the onset of hypertension. Another frequent side effect of the treatment is aggression proneness -but rarely actual aggression- and increased libido.Case report: We present the case of a 17-year old transsexual patient referred for initiation of testosterone treatment. A low in...

Introduction: Insulin is not an optimal treatment in obese type 2 diabetic patients with insulin resistance. We often introduce it as a last resort hoping to improve the metabolic control of our patients. However it is not always effective, and tends to increase body weight, worsen the global cardiovascular risk and cause hypoglycemias. New drugs such as the GLP-1 agonist receptors can be a better alternative and sometimes allow withdrawal of insulin.Cli...